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Coordinated transcriptional and catabolic programs support iron-dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer

Individual compounds were also compared between control and lupus PBL by paired or unpaired t-test with Welchs correction using Prism software (GraphPad, San Diego, CA)

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In addition, proteins that do not fold correctly are targeted for degradation and may require their disulfides to be broken before dislocation across the ER membrane into the cytosol (Ushioda et al