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M1, macrophage M1

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Long term side effects, however, are possible

We did not observe any acute or chronic pathologies in other organs, including the heart (cardiomyocytes, interstitium, and vasculature) and the kidney (glomeruli, tubules, interstitium, and vasculature) (Supplementary Fig

Riboflavin and PLP are also essential cofactors in the kynurenine pathway (Marashly and Bohlega, 2017), where adequate intake of these vitamins has been associated with production of kynurenic acid (Theofylaktopoulou et al., 2014), rather than quinolinic acid, which acts as an agonist to the NMDA receptor, thereby potentiating excitotoxicity (Zinger et al., 2011