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Similarly, studies in thyroid cancer have shown that downregulating MTH1 expression, particularly when combined with drugs regulating the glutathione pool, increases ROS levels in cancer cells

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For example, Cu deficiency has been shown to promote the aberrant hydrophobicity of mutant SOD1, contributing to the impaired interaction of SOD1 and its neuronal toxicity, and this effect could be reversed by the supplementation of Cu

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10.1177/0192623312444471 6 BoulghobraD.GrilletP.-E.LaguerreM.TenonM.FauconnierJ.Fana-BerthonP.et al (2020)

PMID 15209499