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Cortisone injections may provide some relief for conditions including rotator cuff syndrome and rotator cuff tendonitis, but no more significant relief than nonsteroidal anti-inflammatory drugs (NSAIDs), or even placebo drugs in some cases [1]

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doi: 10.1177/107424840000500107

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More serious complications encompass lipid profile alterations, acute pancreatitis, cardiomyopathy, metabolic disturbances, including hyperuricemia, hyponatremia, hypoproteinemia, persistent acidosis, and hypomagnesemia, and bone and mineral metabolism issues such as hypercalciuria, hypocitraturia, kidney stone formation, and urine acidification

Colitis induced bone loss is gender dependent and associated with increased inflammation