DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan building block 458 SMILES CC(C)(C)OC(=O)NCCN1CCN(CC1)C1CCNCC1 Purity (HPLC)

458 SMILES CC(C)(C)OC(=O)NCCN1CCN(CC1)C1CCNCC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

385 SMILES: OC1=CC2=C(C=C1)C1(OC(=O)C3=CC=C(C=C13)C(=O)NCC#C)C1=CC=C(O)C=C1O2 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Wolstenholme

Product Name Pomalidomide-C2-piperazine HCl Synonyms Pomalidomide-4'-C2-piperazine HCl CAS Number n/a Related CAS Molecular Formula C19H25Cl2N5O4 Molecular Weight 458

exhibited longer fluorescence lifetimes than its non-sulfonated counterparts

DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan building block 458 SMILES CC(C)(C)OC(=O)NCCN1CCN(CC1)C1CCNCC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC