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These metabolic dysfunctions interplay with systemic inflammation and oxidative stress, further exacerbating lung injury and worsening patient outcomes

M.JorgeK

Molecules 26 (2021)

doi: 10.1056/nejm199905063401803 139 MinchinR

This intensity gated systemic redox signaling model is illustrated in Figure 6, where the signal is released into the blood stream in response to the high intensity exercise and activates Nrf2 signaling in the contralateral unstimulated muscle, while low intensity muscle stimulation does not meet the threshold to propagate a systemic redox signaling response