Mal-Propionyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-MMAE Size:1mg 877 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCC(O)=O)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

877 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCC(O)=O)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase

Product Name DOTA-C5-alcohol Synonyms CAS Number n/a Related CAS Molecular Formula C21H39N5O8 Molecular Weight 489

794 Purity (HPLC) >= 95% Solubility DMSO

405 SMILES [N-]=[N+]=NCCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-MMAE Size:1mg 877 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCC(O)=O)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate