VHL-CLIP-5C Size:100nmol 93 SMILES: [O-]S(=O)(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S(=O)(=O)NCCOCCOCCOCC#C Purity (HPLC):

93 SMILES: [O-]S(=O)(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S(=O)(=O)NCCOCCOCCOCC#C Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

556 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Endogenous tagging enabled the visualization and the selective depletion of a SNAP-clathrin light chain fusion protein using SNAP-PROTACs

CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCCCN=[N]#N)=[N+](C)C)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Product Name Biotin-PEG3-azide Synonyms CAS Number 875770-34-6 Related CAS Molecular Formula C18H32N6O5S Molecular Weight 444

VHL-CLIP-5C Size:100nmol 93 SMILES: [O-]S(=O)(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S(=O)(=O)NCCOCCOCCOCC#C Purity (HPLC):VHL CLIP 5C is a CLIP PROteolysis TArgeting Chimera (CLIP PROTAC), which recruit the VHL or CRBN ubiquitin E3 ligases to induce the degradation of CLIP fusion proteins. The addition of PROTACs to the CLIP tag reagent toolbox facilitates the comprehensive analysis of protein function with a single gene tagging event. Product Name VHL CLIP 5C Synonyms CAS Number N A Related CAS N A Molecular Formula C42H54N8O6S Molecular Weight 799 Purity (HPLC) >= 95%