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6.0 6.1 6.2 6.3 Cordeiro MF, Gandolfi S, Gugleta K, Normando EM, Oddone F

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For instance, in glucose-deficient glioblastoma, heightened SLC7A11 expression leads to the generation of ROS and oxidative stress through the consumption of intracellular NADPH during the conversion of imported L-cystine to L-cysteine ( in vivo , within a tumor microenvironment, where the metabolic reprogramming associated with altered SLC7A11 expression was evident ( in vivo experiments demonstrated that heightened SLC7A11 expression facilitated localized tumor growth while impeding tumor migration

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PMID: 142 WangHJiangWHuYWanZBaiHYangQet al

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