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Clozapine In psychotic patients (n=1 1), no interaction was observed when valproate was coadministered with clozapine

Freshly methylated CpGs lead to the recruitment of so-called repressor proteins, which inhibit the interaction between DNA and transcription factors

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Zonal necrosis [edit] This is the most common type of drug-induced liver cell necrosis where the injury is largely confined to a particular zone of the liver lobule