Mal-Acetyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-MMAE exatecan Product Name Lenalidomide-PEG3-OH Synonyms Lenalidomide-4'-PEG3-OH

Product Name Lenalidomide-PEG3-OH Synonyms Lenalidomide-4'-PEG3-OH CAS Number n/a Related CAS Molecular Formula C19H25N3O6 Molecular Weight 391

Rational discovery of molecular glue degraders via scalable chemical profiling

388 Purity (HPLC) >= 95% Solubility DMSO

328 SMILES OCCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

hydroxyethoxy)

Mal-Acetyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-MMAE exatecan Product Name Lenalidomide-PEG3-OH Synonyms Lenalidomide-4'-PEG3-OHSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate