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Matzuk MM, Burns KH, Viveiros MM, Eppig JJ

11 If necessary this treatment is repeated within several hours, making the total dose 10 grams

& Tuczek, F

methanogenesis and slower transit in IBS-C), yet effect directions and magnitudes differ across cohorts, and individual treatment response remains variable

Further, NAPQI is conjugated with glutathione to form acetaminophen-glutathione conjugate (APAP-SG) causing a significant glutathione depletion and oxidative stress leading to cell impairment or death (Jaeschke and Bajt 2006