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Multiple drugs can induce ferroptosis in cancer cells, directly or indirectly, by various mechanisms 21,22,23

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There are now three different forms of SOD found in mammalian cells including extracellular superoxide dismutase (EcSOD, SOD3), manganese superoxide dismutase (Mn-SOD, SOD2), and copperzinc superoxide dismutase (Cu,Zn-SOD, SOD1) [15]

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