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Docetaxel is a phase M period-specific drug that promotes tubule polymerization into stable microtubules and inhibits their polymerization, thus significantly reducing the number of tubules and destroying the microtubule network structure, leading to the formation of stable non-functional microtubules, thus disrupting the mitosis of tumor cells (73)

However, their transplantation into a rat model of PD resulted in transient survival without differentiation into neuronal cells, as they did not express neuronal markers such as neuronal beta-tubulin III or TH at the transplantation sites

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doi:10.1038/s41593-018-0195-0

Methods 262, 217227