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The internal pause allows the residual pressure inside the and the subcutaneous tissue fluid pressure to reach physical equilibrium

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Beyond the production of ROS, macrophages also employ an array of directly antimicrobial mechanisms, e.g., the generation of reactive nitrogen species (RNS) in the phagosome and the delivery of cathepsins and other hydrolases into maturing phagosomes [59,225,226,227,228,229,230]