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Using them at different times of day prevents problematic interactions

Conclusion Two thirds of an unselected group of ME/CFS patients treated for 3 months with vitamin B12 nasal drops had a favorable outcome in objective measures and subjective patient reported outcome, which were associated with a significant increase in serum vitamin B12 levels

21 The bioavailability of sublingual vitamin B 12 appears to be equivalent to oral vitamin B 12 , but there is no evidence that sublingual delivery offers any advantage over oral preparations

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The American Diabetes Association recommends periodic B12 monitoring in patients on metformin, with annual monitoring for those on metformin more than 4 years