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congenital forms are rare autosomal disorders characterized by neonatal hypertension, hyperkalemia, increased renin activity and aldosterone concentration

After 48 h, cultures were treated with 10 M cytosine arabinoside (MCE, Cat#HY-13605) to suppress fibroblast proliferation, followed by a 3-day expansion in growth medium

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Concurrent reductions occurred in purine/pyrimidine metabolites essential for nucleotide synthesis and energy supply, including guanosine, uracil, adenine, uridine monophosphate (UMP), inosine monophosphate (IMP), and adenosine diphosphate (ADP) (Fig