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Bruce Ames illustrious scientific contributions ranged from understanding the relationship between mutagenesis and carcinogenesis, to the role of oxidative stress and DNA damage plays in mitochondrial decay and aging ( Salmonella typhimurium in the 1960s and ultimately led to the development of the Ames Test for mutagens

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Therefore, a decrease in xCT inhibits the intracellular import of cysteine, leading to less glutathione synthesis, lower GPX4 activity, and ultimately the accumulation of lipid hydroperoxides, which is linked to loss of plasma membrane integrity 35

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