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Additionally, coagulation profiles (prothrombin time/INR) must be closely monitored, as worsening coagulopathy indicates declining hepatic synthetic function and may signal impending liver failure [30]

Therefore, future clinical translation will probably benefit from biomarker-guided frameworks, incorporating (1) FSP1 abundance/localization, (2) CoQ pool size and redox state, (3) lipid peroxidation signatures and (4) metabolic context (mitochondrial activity and sulfur/selenium flux)

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(47) found that CUR significantly restored motor coordination and antioxidant activity and improved mitochondrial function in a rotenone-induced PD mouse model

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Animals were housed in groups of 5 animals per cage at 22 1C and exposed to 12:12 h lightdark cycle and had access to food and water ad libitum