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Interestingly, intracellular ferritin was increased in the IB3-1 cells at baseline compared to the C38 cells (Additional file 1: Fig

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Mechanism Comparison Shared Pathway Both peptides activate GHSR-1a on pituitary somatotrophs, triggering: GHSR-1a Gq/11 PLC IP + DAG intracellular Ca release PKC activation Ca influx GH vesicle exocytosis This is fundamentally different from how GHRH analogs (CJC-1295, Sermorelin) work (GHRHR Gs cAMP PKA), which is why combining either GHRP with a GHRH analog produces synergistic GH release (Veldhuis et al., 2009)

Notably, only specific lipids may foster early peroxidation events followed by non-specific oxidation of other lipids

Dingli, David