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Tudor M, Jandric I, Marovic A, et al

The theoretical concern worth taking seriously is angiogenesis

Another potential therapeutic, Minocycline is a microglial inhibitor which reduces BBB dysfunction by preventing production of glutamate, matrix metalloproteinases, and the proinflammatory cytokine, IL-1, and increasing the levels of cells responsible for the remyelination of neurons which would be relevant in treating AD [138, 140,141,142]

showed that transforming growth factor (TGF)- type II receptor knockout in mice gave rise to prostate and gut epithelial tumors by activating c-MET through paracrine overexpression of HGF by stromal cells [96]

Following the remodelling phase, a higher proportion of synthesised type I collagen, a corresponding decrease in cellularity, glycosaminoglycan content and type III collagen (Sharma and Maffulli 2005) can be observed