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All chronic diseases, including COVID-19 with the long-COVID-19-syndrome (271), are characterized by the presence of persistent chronic inflammation and sustained generation of reactive oxygen and nitrogen species that when confronted with inadequate antioxidant defenses (likely leading components of anti-inflammaging) precipitate excessive oxidative stress

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this suggests that adenosine may act as a homeostatic regulator of sleep, with higher levels promoting the need for rest (Huang et al., 2014)

(Proposed catalytic cycle: Fig

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doi: 10.1016/j.rmed.2013.02.007