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In tumor therapy, engineered magnetic microspheres induce TAMs polarization to the M1 phenotype through the TLR4/NF-B pathway, which reduces the expression of SLC7A11 in tumor cells and thus increases ferroptosis sensitivity (234)

The three arms of ibutamoren point towards three different directions, mimicking the first four residues of ghrelin, Gly1-Phe4, including the octanoyl moiety (Fig