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Excessive mtROS production and subsequent activation of inflammasomes play a critical role in the pathophysiology of sepsis, driving uncontrolled inflammation and multi-organ failure

In recent years, small fish such as medakas and zebrafish, have gained attention as new model organisms

In addition, immune complexes activate the complement system and induce NLR family pyrin domain containing 1 (NLRP1) inflammasome activation to release IL-1, thus dysregulating pro-inflammatory pathways (60, 92)

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doi: 10.1016/j.urology.2013.03.065 34 Fong-NgernK.VinaiphatA.ThongboonkerdV

The lytic activity was associated with the embedding of p15(E) in the virus membrane whereas gp70 projects further from the membrane