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We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)

Smoking can lead to an increased risk of developing lung cancer, diabetes, heart disease, stroke, and chronic obstructive pulmonary disease (COPD)

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That's a third more than ZYN's 15-count can, which is why Rogue is one of the best-value nicotine pouches on the market

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