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Connexins also exert numerous nonchannel functions: they regulate astrocyte morphology and interactions with synapses, influence gene expression, control glial reactivity and modulate mitochondrial function and ATP production 475,476,477

Unfortunately, glutathione levels may be reduced by several factors, including poor nutrition, environmental toxins, stress, and also decline with age

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In addition, cardiac glycoside ICD inducers such as oleanolide can also trigger ERS by blocking Na + /Ca 2+ exchange, which will enrich and promote ROS production in mitochondria, thus activating the PERK/eIF2/ATF4/CHOP pathway and inducing ICD (115)

Subsequently, T cell generate adenosine triphosphate (ATP) to support the metabolic demand for their survival and function

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