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a model of endothelial cell culture was used to mimic the environment of pulmonary hypertension, combining both chemical and physical stimuliNPs and cyclic stretch, respectively [220]

P., Chen, X

Maquart, Pickart, and colleagues established this in fibroblast culture in 1988 ( FEBS Letters ) and confirmed it in vivo in rat wound models in 1993 ( Journal of Clinical Investigation ) 5 6

So to see studies like these supporting

Moreover, PHA665752 supressed cell proliferation, and induced apoptosis in MHCC97-L and MHCC97-H cells which overexpress c-Met through blocking phosphorylation of c-Met and downstream PI3K/Akt and MAPK/Erk pathways (You et al., 2011)