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In addition, ROS induce matrix degeneration through the upregulation of matrix-degrading enzyme expression while this effect is abolished by antioxidant treatment 123,125

Thus, in HG-injured ARPE-19 cells, we assessed the impact of Khavinson Peptides Epitalon (20, 40, and 60 ng/mL) on the wound-healing process, evaluated in a tissue culture plate using real-time imaging (IncuCyte S3 Live-Cell Analysis System) [26]

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These observations are contradictory to the qPCR data observed by Van de Poel et al