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This incretin effect is considerably attenuated in people with type 2 diabetes (see Figure 1), a loss that is even considered an early indicator of the disease, but it was observed that this deficit could be completely corrected by the continuous infusion of GLP-1 to diabetic patients

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These rates compare favorably with the Phase 2 discontinuation rates (10-17%), likely reflecting the improved dose-escalation schedules used in Phase 3

Fulvestrant is the first SERD approved for clinical use to treat advanced and metastatic breast cancer

The rapid attainment of peak plasma levels with parenteral administration makes this formulation particularly suitable for acute correction of deficiency states or for protocols requiring high systemic exposure