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Sullivan, K

In the context of LIPO-C, its primary role is as a lipotropic agent, helping to prevent the buildup of excess fat in the liver

8 This effect increased with duration of therapy, and patients had an unclear prophylactic supplementation response

This distinguishes it from full-length GH and means that at research-relevant concentrations, the fragment does not produce the insulin resistance, glucose dysregulation, or tissue proliferation associated with GHR-mediated GH signalling allowing isolated study of the GH lipolytic mechanism without these confounding effects

Dual agonists (e.g., Tirzepatide): Act on both GLP-1 and GIP receptors to more vigorously improve blood sugar control and weight loss