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Description

Ahmad Jamil H, Abdul Karim N

To determine whether oxidation-reduction reactions involve glutathione or its anions, we created CASSCF(14, 13) models for geometric optimization, similar to those shown in Fig

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Importantly, overexpression of TrxR1 significantly reversed PLTXinduced GSH depletion, the decrease in GPx4 activity, and MDA accumulation, confirming the central role of TrxR1 in PLTX toxicity