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Or SubQ protocols where the loading phase drags on for two weeks because peak plasma levels never quite reach the threshold needed to observe the metabolic shift the study was designed to detect

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Meanwhile, in our opinion, programmed cell death, particularly apoptosis, could be added to this axis because the mechanisms of apoptosis and other forms of programmed cell death are inextricably linked to the mitochondria, mTOR, and autophagy

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Therefore, FXR not only plays an important regulatory role in lipid metabolism but is also a key transcription factor in glucose homoeostasis (Reference Kim and Fang27,Reference Pathak, Xie and Nichols28)