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Under physiological conditions, about three-quarters comes from senescent erythrocytes undergoing catabolism in the reticuloendothelial system, which contains splenic macrophages and hepatic Kupffer cells, and the remaining one-quarter of hemoglobin comes from ineffective red blood cell production and enzymes containing hemoglobin (4)

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1.4% in the active control group

Saudi J Biol Sci 2018;25:57885

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