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Earlier studies showed that in the cerebral I/R model, oxidative stress enhances transcription factors such as NF-B, which is distributed in the neurons, microglial cells, and astrocytes

Additionally, IL-6 and IL-23 can drive Th 17 differentiation, with IL-17 recruiting neutrophils that infiltrate thyroid tissue, causing direct damage to follicular epithelial cells (Stadhouders et al., 2018)

Cell signaling is crucial for communication between organs and the nervous system, as well as between the brain and endocrine system

However, clinical trials investigating intravenous or intranasal GSH showed improvements in PD symptoms but lacked statistical significance over placebo, suggesting a higher dose might be required (203205)

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Hamidi S, Maniakas A, Akhave NS, Banuchi VE, Busaidy NL, Dadu R, Ferrarotto R, Guise TA, Hofmann MC, Hosseini SM, Hu MI, Iyer PC, Mansour M, Marczyk VR, Roy-Chowdhuri S, Sherman SI, Sousa LG, Wang JR, Williams MD, Zafereo ME , Waguespack SG, Cabanillas ME