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Even more successful than normal cells was nebulized docetaxel NE (MRC-5 cells) against tumor cells (A-549 cells), creating a standard framework for coencapsulating gemcitabine (GEM) and PTX with a ligand that targets the glucose receptor (172)

Oncology 66 (3), 201209

The GNCsiRNA complex potently downregulates the NGF expression in Panc-1 cells and in pancreatic tumours, and effectively inhibits the tumour progression in three pancreatic tumour models (subcutaneous model, orthotopic model and patient-derived xenograft model) without adverse effects

All efforts were made to follow the Replacement, Refinement and Reduction guidelines

Valko M, Leibfritz D, Moncol J, et al

Elevated expression of Nrf2 mediates multidrug resistance in CD133+ head and neck squamous cell carcinoma stem cells