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We elucidate the role of platelets in ICH pathophysiology and highlight the limitations of the current treatment options and advancements in preclinical research on the application of HPL in neurological disorders

The IF staining and Western blot analyses for -H2AX, a marker for DNA double-strand damage, and phosphorylated nucleophosmin 1 (pNPM1) required for DNA damage repair were performed in RSL3-treated K1 cells

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Studies were eligible regardless of administration route, dosing regimen, treatment duration, or sex, provided that interventions were applied postnatally to maintain translational relevance

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