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438 Notably, two cytokines involved in the mt-ISR, FGF-21 and GDF-15, have shown exceptional diagnostic value for mitochondrial myopathy and tRNA gene mutation-related mitochondrial diseases, and they may also serve as biomarkers for monitoring therapeutic efficacy

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In the pivotal 2017 Cell paper quoted earlier, one of the unexpected benefits was increased fur density in mice treated with FOXO4-DRI: Underscoring their aging phenotype, XpdTTD/TTD mice show accelerated loss of hair