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Comment: Several commenters appreciated our attempt to account for the underutilization of CCM services in the proposed valuation, but one commenter asserted that those adjustments still only account for the resources associated with CCM and not the increased work or practice expenses incurred with maintaining practice-level advanced primary care capabilities or providing APCM services to more beneficiaries

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Shan et al., 2018) paradoxical activation of the default mode network (DMN) after physical exercise (Rayhan and Baraniuk, 2021), and from reduced regional fluorodeoxyglucose (FDG) uptake in the right mediofrontal cortex, brain stem (Tirelli et al., 1998) and orbitofrontal cortex (Siessmeier et al., 2003), indicating hypometabolism (Shan et al., 2020)

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M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy