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4.4.1 Glutamine Glutamine metabolism not only promotes the synthesis of succinic acid by fueling the TCA cycle in M1-type macrophages, but also drives M2 polarization via the conversion to glutamate and then -KG, with high -KG levels and a high -KG/succinate ratio facilitating macrophage reprogramming towards the M2 phenotype (Liu et al., 2017)

Selenoproteins such as GPXs and TRs can scavenge H2O2, protect cell membrane structure and function, repair the site of molecular damage, achieve anti-oxidative stress and local protective effects against oxidative stress or inflammation

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Tai Y, Pu M, Yuan L et al (2021) miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes