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Neuroscience 388 , 6986

10.1038/s41422-020-00441-1 245 TangG.PiL.GuoH.HuZ.ZhouC.HuQ.et al (2022)

demonstrate that PINK1 and PRKN deficiency accelerates pancreatic tumorigenesis through mitochondrial iron accumulation, which accelerates KRAS-driven PDAC initiation by enhanced ROS formation, immune suppression and metabolic reprogramming from OXPHOS to glycolysis [58]

Concurrently, it is imperative to disentangle the concrete regulation on functional subgroups of the gut microbiota induced by metabolites from articular ferroptosis (for example, ROS and LPO) (such as probiotic genus composition, abundance of populations such as those of Lactobacillus and the Bacteroidetes/ Firmicutes ratio) and gut structural mucosal barrier integrity (for example, the expression of tight junction proteins, such as occludin and claudin)