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Aside from generating both NADPH and ribose 5-phosphate, the PPP can operate four different modes where NADPH and/or ribose 5-phosphate is produced, depending on the cellular metabolic demands (Fig

There are six main IGF binding proteins in circulation (IGFBP-1 through IGFBP-6), plus several membrane-anchored forms

discovered that acetic acid can mediate the metabolic reprogramming of tumor cells and serve as a precursor to promote the acetylation of c-Myc

Therapeutic doses of vitamin C may act against cancer development and progression through several other mechanisms, such as stimulating immune system activation or enhancing the chemosensitivity of cancer cells, but evidence beyond preclinical models is still lacking (124, 125)

Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation

Curr Pharm Des (2022) 28:206572