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Another study investigated whether the zinc complex of L-carnosine, polaprezinc (3 mg/kg, p.o), inhibited paclitaxel-induced mechanical allodynia and migration of macrophages in dorsal root ganglion cells without affecting the antitumor activity exerted by paclitaxel in cell lines and tumor-bearing mice [145] (Fig

244 In addition, HDAC1 enhances basal autophagy by deacetylating ATG16L1, aiding in autophagosome elongation and supporting nutrient-deprived cell proliferation

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As the COVID-19 pandemic rages on, the opioid crisis has steadily worsened