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Description

2.7 Metabolite analysis Online metabolite databases (KEGG, HMDB, PathBank) and the literature were used to link the statistically significant metabolites to metabolic pathways

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High concentrations of resveratrol may inhibit mitochondrial complex I, while synthetic activators like SRT2104 require high doses due to poor liver targeting, increasing oxidative stress risk in extrahepatic tissues

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While nausea, vomiting, and diarrhea commonly occur with tirzepatideparticularly during dose escalationsevere symptoms may require dose adjustment, temporary treatment interruption, or additional supportive care

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The weight-loss patterns were identical for the two diets, suggesting that neither homocysteine nor cystathionine were contributing to the weight loss (Extended Data Fig

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