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Some medical conditions, including autoimmune disease like shingles (herpes zoster), rheumatoid arthritis or celiac disease, as well as Lyme disease, some cancers, and several other diseases can also cause or increase the risk of nerve damage, also sometimes referred to as peripheral neuropathy

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Vitamin B6 & B12 contributes to normal homocysteine metabolism

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Nature 578:577581 Xiang C, Oliver DJ (1998) Glutathione metabolic genes coordinately respond to heavy metals and jasmonic acid in Arabidopsis