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Studies also in VEGFA-overexpressed human tumors and mouse tumor models revealed that apatinib plus PD-1/PD-L1 blockade therapy could alleviate hyperangiogenesis and hypoxia in TME and also alter the immunosuppressive TME into an immunostimulatory microenvironment [109]

Reported / Possible Side Effects Mild, anecdotal: Occasional reports of mild headache, transient jitteriness, or injection-site reactions