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Pressure-dependent dysregulation of signaling mechanisms in anterior eye is reflected in aqueous humor composition, which shows altered levels of a striking number of signaling molecules that include adenosine, nitric oxide, ATP, endothelin-1 (ET-1), lipids (endocannabinoids, prostaglandins, cholesterol), transforming growth factor (TGF), CTGF (connective tissue growth factor), angiotensin II and cochlin

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Recently, a study indicated that T cells are sensitive to extracellular arginine due to their low expression of the arginine resynthesis pathway enzymes argininosuccinate synthetase (ASS) and ornithine transcarbamylase (OTC)

Murthy SB, Patnana SV, Xiao L, Rohren E, Hofstetter WL, Swisher SG , Liao Z, Lee JH, Bhutani MS, Macapinlac HA, Wang X, Ajani JA