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However, despite the absence of ferritinophagy we found that intracellular ferrous iron levels in IB3-1 cells (but not C38 cells) increased following erastin and FAC exposure, which requires further investigation as the pathways responsible for this increase in redox active iron in response to ferroptotic induction are currently unknown, but will become targets for future treatment interventions

Neuromolecular Med 19(1):147153

Two plasmid-based overexpression systems, pBAV1C-T5- vanAB and pBAV1Cd-chn- vanAB , were transformed into ASA1002, resulting in strains ASA1003 and ASA1004 with constitutive and cyclohexanone-inducible vanAB expressions, respectively

Cells were incubated for 48 h before assay

Yoshizumi K, Hirano K, Ando H, Hirai Y, Ida Y, Tsuji T, Tanaka T, Satouchi K, Terao J (2006) Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase

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