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To further provide disease implications for the gene-to-microbiome regulation, we performed Disease Ontology (DO) analyses on the involved genes (Figs

Such candidate gene approaches can also investigate SNPs based on prior biological knowledge, other known variants in the same pathway as the top SNPs from GWAS, or variants associated with a similar phenotype in an adult population (e.g., SNPs associated with thromboembolism in the general population)

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While preclinical studies show promise, existing clinical evidence primarily comes from small-scale trials with methodological limitations

Due to time and cost constraints, the number of clinical samples collected from the patients in both groups was limited

Clin Diagn Lab Immunol (2005) 12:525