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Optimization of the synthesis conditions by BoxBehnken design (BBD) generated DOX-IR820@MSNMnO 2 nanoparticles with a high loading capacity

Pathway analysis was conducted using fgsea (fast GSEA) R-package (fgsea) with the minimum of 15 and maximum of 500 genes in a pathway and with 1 million of permutations

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Its structural stability remaining intact under various experimental conditions makes it a reliable reference compound for laboratories investigating tissue repair mechanisms, angiogenic signaling, nitric oxide pathway interactions, and gastrointestinal biology in preclinical settings