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Current research does not widely report direct appetite suppression as a primary mechanism for either 5-Amino-1MQ or AOD-9604

[4] Red flag symptoms requiring immediate medical assessment include: progressive or worsening neurological symptoms, changes in vision, significant gait disturbance, or cognitive decline

These schedules are based on the bodys ability to store B12 and are designed to be effective in preventing symptoms

PLoS ONE 10 , e0126910 (2015)

This is a concern that applies to all significant weight loss interventions, not just tirzepatide, but it becomes more relevant as the magnitude of weight loss increases

DOI: 10.1056/NEJMoa0909747